Recent Research by Substance and Year
- Ayahuasca and Mental Health: Depression, Anxiety, Suicidality, Addiction, Eating Disorders, Personality Disorders, Grief
- Ayahuasca and Physical Health: Neurogenesis, Anti-Inflammation, Detoxification
- Iboga and Mental Health: Addiction
- LSD: Neuroscience and Consciousness
- MDMA and Mental Health: PTSD, Therapy
- Psilocybin and Mental Health: Depression, Anxiety, End-of-Life Acceptance
PEx has collected a list of some of the most recent and cutting-edge peer-reviewed scholarly research into psychedelics. Substances are listed in alphabetical order. We are constantly updating this page. Spot an error or have a new study to add? Let us know!
Ayahuasca and Mental Health: Depression, Anxiety, Suicidality, Addiction, Eating Disorders, Personality Disorders, Grief
2021
A placebo-controlled study of the effects of ayahuasca, set and setting on mental health of participants in ayahuasca group retreats
2020
Effects of ayahuasca on mental health and quality of life in naïve users: A longitudinal and cross-sectional study combination
Rapid and sustained decreases in suicidality following a single dose of ayahuasca among individuals with recurrent major depressive disorder: results from an open-label trial
Therapeutic potential of ayahuasca in grief: a prospective, observational study
Modulatory effects of ayahuasca on personality structure in a traditional framework
Personality Traits in Former Spanish Substance Users Recovered with Ayahuasca
Pilot Evaluation of a Residential Drug Addiction Treatment Combining Traditional Amazonian Medicine, Ayahuasca and Psychotherapy on Depression and Anxiety
The ritual use of ayahuasca during treatment of severe physical illnesses: a qualitative study
2019
Ayahuasca: Psychological and Physiologic Effects, Pharmacology and Potential Uses in Addiction and Mental Illness
Acute effects of ayahuasca in a juvenile non-human primate model of depression
Ayahuasca improves emotion dysregulation in a community sample and in individuals with borderline-like traits
2018
Rapid antidepressant effects of the psychedelic ayahuasca in treatment-resistant depression: a randomized placebo-controlled trial
Cortisol Modulation by Ayahuasca in Patients With Treatment Resistant Depression and Healthy Controls
Four Weekly Ayahuasca Sessions Lead to Increases in “Acceptance” Capacities: A Comparison Study With a Standard 8-Week Mindfulness Training Program
Long-term effects of ayahuasca in patients with recurrent depression: a 5-year qualitative follow-up
Is Ayahuasca an Option for the Treatment of Crack Cocaine Dependence?
Sub-acute and long-term effects of ayahuasca on affect and cognitive thinking style and their association with ego dissolution
2017
Nourishing the Spirit: Exploratory Research on Ayahuasca Experiences along the Continuum of Recovery from Eating Disorders
Assessing the Psychedelic “After-Glow” in Ayahuasca Users: Post-Acute Neurometabolic and Functional Connectivity Changes Are Associated with Enhanced Mindfulness Capacities
Potential Use of Ayahuasca in Grief Therapy
Ayahuasca and Physical Health: Neurogenesis, Anti-Inflammation, Detoxification
2020
N,N-dimethyltryptamine compound found in the hallucinogenic tea ayahuasca, regulates adult neurogenesis in vitro and in vivo
Subacute effects of the psychedelic ayahuasca on the salience and default mode networks
Anti-inflammatory activity of ayahuasca: therapeutical implications in neurological and psychiatric diseases
2019
Purging and the body in the therapeutic use of ayahuasca
Ayahuasca, an ancient substance with traditional and contemporary use in neuropsychiatry and neuroscience
Ayahuasca: Uses, Phytochemical and Biological Activities
Iboga and Mental Health: Addiction
2021
Novel treatment of opioid use disorder using ibogaine and iboga in two adults
2020
Ibogaine therapy for addiction: Consumer views from online fora
2019
Biosynthesis of an Anti-Addiction Agent from the Iboga Plant
Ibogaine and Subjective Experience: Transformative States and Psychopharmacotherapy in the Treatment of Opioid Use Disorder
2018
Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study
Ibogaine Detoxification Transitions Opioid and Cocaine Abusers Between Dependence and Abstinence: Clinical Observations and Treatment Outcomes
Ibogaine as a treatment for substance misuse: Potential benefits and practical dangers
Breaking the cycle of opioid use disorder with Ibogaine
Understanding the Healing Potential of Ibogaine through a Comparative and Interpretive Phenomenology of the Visionary Experience
Changes in Withdrawal and Craving Scores in Participants Undergoing Opioid Detoxification Utilizing Ibogaine
LSD: Neuroscience and Consciousness
2021
Lysergic acid diethylamide (LSD) promotes social behavior through mTORC1 in the excitatory neurotransmission
2019
Effective connectivity changes in LSD-induced altered states of consciousness in humans
2018
Changes in global and thalamic brain connectivity in LSD-induced altered states of consciousness are attributable to the 5-HT2A receptor
Long-lasting subjective effects of LSD in normal subjects
2017
Alterations of consciousness and mystical-type experiences after acute LSD in humans
MDMA and Mental Health: PTSD, Therapy
2020
Long-term follow-up outcomes of MDMA-assisted psychotherapy for treatment of PTSD: a longitudinal pooled analysis of six phase 2 trials
2019
MDMA-assisted psychotherapy for treatment of PTSD: study design and rationale for phase 3 trials based on pooled analysis of six phase 2 randomized controlled trials
Breakthrough for Trauma Treatment: Safety and Efficacy of MDMA-Assisted Psychotherapy Compared to Paroxetine and Sertraline
Perceived Benefits of MDMA-Assisted Psychotherapy beyond Symptom Reduction: Qualitative Follow-Up Study of a Clinical Trial for Individuals with Treatment-Resistant PTSD
2018
Progress and promise for the MDMA drug development program
2017
MDMA and PTSD treatment: “PTSD: From novel pathophysiology to innovative therapeutics”
Potential Psychiatric Uses for MDMA
Therapeutic effect of increased openness: Investigating mechanism of action in MDMA-assisted psychotherapy
Psilocybin and Mental Health: Depression, Anxiety, End-of-Life Acceptance
2021
What is the clinical evidence on psilocybin for the treatment of psychiatric disorders? A systematic review
2020
Effects of Psilocybin-Assisted Therapy on Major Depressive Disorder
Psilocybin as a New Approach to Treat Depression and Anxiety in the Context of Life-Threatening Diseases—A Systematic Review and Meta-Analysis of Clinical Trials
Depression, Mindfulness, and Psilocybin: Possible Complementary Effects of Mindfulness Meditation and Psilocybin in the Treatment of Depression. A Review
Psilocybin-assisted therapy of major depressive disorder using Acceptance and Commitment Therapy as a therapeutic frame
Psilocybin occasioned mystical‐type experiences
Psilocybin and LSD in the Treatment of Depression and Anxiety
2018
Psilocybin with psychological support for treatment-resistant depression: six-month follow-up
Quality of Acute Psychedelic Experience Predicts Therapeutic Efficacy of Psilocybin for Treatment-Resistant Depression
Increased amygdala responses to emotional faces after psilocybin for treatment-resistant depression
Increased nature relatedness and decreased authoritarian political views after psilocybin for treatment-resistant depression
2017
Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms
Patients’ Accounts of Increased “Connectedness” and “Acceptance” After Psilocybin for Treatment-Resistant Depression
